黄体酮对雌性家兔十二指肠肌电活动作用的数学模型研究

doi:10.11843/j.issn.0366-6964.2018.12.021

Abstract

Abstract:

This study was conducted to explore the characteristics of progesterone on duodenal smooth muscle activity and to establish a mathematical model to reveal its mechanism. In this experiment, rabbits were grouped according to the dosage of progesterone containing 0, 0.5, 1.0, 1.5 and 2.0 mg·kg^-1. The corresponding dose of progesterone was injected intramuscularly into the ovariectomized and electrode implanted rabbit models. The changes of myoelectric activity in the duodenum of the experimental group were collected by BL-420F biological function test system. Using myoelectric activity index as dependent variable and progesterone dose as independent variable, a mathematical model was constructed to reveal the mechanism of progesterone on duodenal smooth muscle activity. The results showed that:1) In the dose range of 1.0-2.0 mg·kg^-1, the amplitude, frequency and myoelectric activity index of duodenal myoelectric activity increased firstly and then decreased with the increase of progesterone dose, that is, concentration-dependent regulation mode. 2) A functional model of progesterone dosage and myoelectric activity index was constructed, which accord with the basic change characteristics of Gauss function. The accuracy of the function fitting analysis showed that the R²=0.998 0 and P=0.001 4, suggesting the fitting accuracy of the model was very high. 3) According to this function, the myoelectric activity index changed significantly in the range of 0.72-1.98 mg kg^-1 of progesterone, ranging from 1.64 to 4.92 mV min^-1. At the same time, the dosage of progesterone of 1.14, 1.35 and 1.56 mg·kg^-1 were the boundary point. The change trend of myoelectric activity index was continuous exponential type increase, logarithmic type increase, exponential type decrease and logarithmic type decrease. The above results suggest that the regulation of progesterone on the electrical activity of duodenal smooth muscle is based on a certain level of myoelectric activity in the duodenum. The results of this study provide a very important theoretical basis and reference for clarifying the mode of progesterone regulating duodenal movement and the development and use of progesterone drugs.

CLC Number:

S852.2

DU Yi-nan, XIN Xian-meng, ZHAO Jian-shuai, ZHANG Jin, HUANG Shuang, GUO Ya-ru, ZHANG Ying-li, XU Yong-ping. The Study of Mathematic Model of Progesterone on the Regulation of Duodenal Myoelectric Activity of Female Rabbit[J]. ACTA VETERINARIA ET ZOOTECHNICA SINICA, 2018, 49(12): 2715-2722.

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The Study of Mathematic Model of Progesterone on the Regulation of Duodenal Myoelectric Activity of Female Rabbit

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